History of diethylstilbestrol use in cattle
نویسندگان
چکیده
The first demonstration of growth stimulation in cattle with hormone supplementation took place in 1947 by investigators at Purdue University using diethylstilbestrol (DES) in heifers. These studies on DES used a compressed tablet as a subcutaneous implant. Side-effects, such as vulvar swelling, riding, and mammary development, were observed. Scientists at Iowa State College later investigated the efficacy of DES administered orally. Growth stimulation and improved feed utilization were observed in both sheep and cattle, and fewer side-effects were reported with oral use. These studies also demonstrated reduced carcass grade and increased leanness. Orally administered DES for cattle was approved by the U.S. Food and Drug Administration in 1954, and its use in growing-finish
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